Semorelin is an acetate salt which was developed as an amidated synthetic peptide with a 29 amino acid chain. This peptide corresponds to the amino terminal segments that naturally occur along hormone chain, leaving behind 44 amino acid residuces. Semorelin is developed using a free base with the empirical formula C 149 H 246 N 44 O 42 S. This peptide contains a 2258 dalton molecular weight. This peptide is designed to be non-pyrogenic and sterile for animal applications.
Semorelin is typically produced as a lyophilized powder that is to be reconstituted using sodium chloride so it can be applied to animal tissues via injection as necessary. A reconstituted solution of semorelin should have a pH between 5 and 5.5 for ideal results and minimal side effects afterward.
Researchers should read the pH information on the container when using Semorelin to determine what type of buffer has been added to the solution. This will determine how much fluid will be needed to reconstitute the formula with the proper pH balance.
Pegylation of GRF
Synthetic GRF 1-29 contains amino acid compositions that are identical to the terminal 29 amino acid sequent and maintains identical bioactivity in vivo.
Drawbacks associated with this chemical include its short half-life which can be 10-20 minutes. Pegylation has been considered a valid approach to obtain stable forms of this peptide with a longer half-life.
Pegylated GRF conjugates were obtained, based on their bioactivity which was tested in vivo and in vitro, to determine their effects. Each serum was injected in rats and pigs to find the GRF-PEG conjugates that could bind with active stores of GRF receptors known to come with a varying potency.
Mono pegylated isomers were linked to effective biological activity in vitro which was similar to hGRF 1-29.
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Effects of Long-Term Administration
To find a chronic GHRH level capable of improving growth rates without depleting the contents of the pituitary, female rats were administered soamtostatin, GHRH and sermorelin for a 19 day cycle.
During a second study rats were treated with GHRH for 21 days with slow release pellets and combined injections.
During the first experiment body weight was increased the most with administrations of GHRH, which only slightly decreased pituitary content.
Hypthalamic concentrations of SS were decreased when peptides were administered alone, but this did not affect the perameter.
This research implies that GHRH is not effective enough to increase body weight but if it is combined with other peptides, such as semorelin or somatostain, it may be able to increase female responsiveness to these peptides.
Addressing Age-Associated Hormone Insufficiency
Age-management medications focus on addressing failing neuroendocrine function from hormone deficiencies.
One of the most common means of addressing these insufficiencies is hormone therapy, which can help to address hormonal insufficiencies that lead to age results.
While this therapy is efficient in addressing degenerative aging effects it does not treat neuroendocrine decline, and in some cases may accelerate this damage. Certain therapy has been researched as a means of better addressing this need.
Certain stimulants such as semorelin or GHRH are injected into animal test subjects to stimulate a more youthful endocrine physiology.
Practitioners of age management pharmaceutical aids hope that research will develop new peptide administration techniques that could improve these treatment options.
Semorelin is generally used in research as a means of evaluating the function of the pituitary gland in animals. It may also be used as a means of increasing growth in immature animals. In some cases research indicates that semorelin can be applied to animals, to see an improvement in hormone deficiencies that stem from an acute disorder or the aging process.